Research Interests

Reconstruction and integration of metabolic network and gene regulatory network.
Multi-Omics analysis and integration.
Metabolic flux analysis and application for metabolic engineering.
Identify targets and biomarkers for cancer and metabolic disease.
Comparative analysis and evolutionary significance of metabolic networks between C3 and C4 plants.


  1. Wang Z, Danziger S, Heavner B, Ma SY, Baliga N, Aitchison J, \ Price N. Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast. PLoS Computational Biology, 2016, bioRxiv doi:10.1 101/087148.
  2. Wang Z, Lu LY, Liu L, Li J. Coordination of plant primary metabolism studied with a constraint-based metabolic model of C3 mesophyll cell. Biomed Research International.2016 (accepted)
  3. Shen FZ, Li J, Zhu Y, Wang Z*.Systematic investigation of metabolic reprogramming in different cancers based on tissue-specific metabolic models. Journal of Bioinformatics and Computational Biology, 2016, (4) 5: 1644001.
  4. Wang Z, Danziger S, Heavner B, Ma SY, Price N. Integrated model of gene regulation and metabolism improves phenotype prediction in Saccharomyces Cerevisiae. International COBRA conference, 2015,9.
  5. Liu L, Shen FZ, Xin CP, Wang Z*. Multi-scale analysis of Arabidopsis response to different CO2 conditions: from gene expression to metabolic flux. Journal of Integrative Plant Biology. 2015, 12370.
  6. Wang CL, Guo LY, Li YX, Wang Z*. Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis. BMC Systems Biology, 2012, 6: S9.
  7. Wang CL, Guo LY, Wang Z*. Comparative Analysis of C3 and C4 Plants using Constraint-based Model. The Fourth International Symposium on Plant Growth Modeling, Simulation, Visualization and Applications, 2012, Shanghai. (EI)
  8. Wang J, Wang Y, Liu L, Wang Z*, Zhu XG*, Ma XT*. Synchronization of cytoplasmic and transferred mitochondrial ribosomal protein gene expression in land plants is linked to Telo-box motif enrichment. BMC Evolutionary Biology, 2011, 11:161.
  9. Chang X, Wang Z, Hao P, Li YY, Li YX. Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks. Genomics, 2010, 95: 339?344.
  10. Chen Q, Wang Z*, Wei DQ. Progress in the applications of flux analysis of metabolic networks. Chinese science bulletin, 2010, 55(22): 2315-2322.
  11. Wang Z, Zhu XG, Chen YZ, Li YX, Liu L. Though with constraints imposed by endosymbiosis, preferential attachment is still a plausible mechanism responsible for evolution of chloroplast metabolic network. Journal of Evolutionary Biology, 2009, 22(1): 71-79.
  12. Wang Z, Chen Q, Liu L. Relationship between topology and functions in metabolic network evolution. Chinese science bulletin, 2009, 54 (5): 776-782.
  13. Chen HF, Wu MY, Wang Z, Wei DQ. Insight into the Metabolism Rate of Quinone Analogues from Molecular Dynamics Simulation and 3D-QSMR Methods. Chem Biol Drug Des. 2007, 70: 290-301.
  14. Wang Z, Zhu XG, Chen YZ, Li YY, Hou J, Li YX, Liu L. Exploring photosynthesis evolution by comparative analysis of metabolic networks between chloroplasts and photosynthetic bacteria. BMC Genomics, 2006, 7: 100.
  15. Wang Z, Zhu XG, Chen YZ, Li YX, Liu L. Comparison of modularization methods in application to different biological networks. Lecture Notes in Computer Science, 2006, 4316: 185-195.
  16. Wang Z, Chen YZ, Li XY. A brief review of computational gene prediction method. Genomics, Proteomics and Bioinformatics. 2004, 2(4): 216-221.