Dr. Chaochun Wei, Department of Bioinformatics and Biostatistics

Research

Research interests:

• functional element finding in genomes, such as
• protein coding gene structure prediction
• alternative splicing prediction
• regulatory element finding
• gene regulatory network reconstruction
• metagenomics
• high performance computing for bioinformatics

Major research contents are comparative-genomics and biological sequence analysis methods and systems for data generated by the next-generation sequencing technologies. These methods and systems can improve the understanding of some biological processes by sequence information, such as the impact of genome sequence mutations on pathogenicity of microbes, alternative splicing, gene expression regulation and host-environment interactions. The final goal is to apply these knowledge to medical diagnose, disease therapy and disease prevention.

Grants:
• National Natural Science Foundation of China(NSFC)
• "Finding and characterizing complex structure sequence modules in metagenomes"(61472246, PI, RMB 800K ) (2015.1-2018.12)
• "Finding and characterizing of genes containing repeat regions"(61272250, PI, RMB 800K ) (2012.1-2016.12)
• National High-Tech R&D Program (863)
• "Integration and analysis of omics data for microbes" (2014AA021502, RMB 650K)(2014.1 - 2016.12)
• National Basic Research Program of China(973)
• "The degradation methanism of coral reefs in South China Sea and their restoration potential" (2013CB956103, Co-PI, RMB 1.04M(total 5.72M))(2013.1-2017.12)

Finished grants:
• National Natural Science Foundation of China(NSFC)
• "An index measuring the gene structure variations and its application in the study of disease susceptibilities of genes"(60970050, PI, RMB 300k)(2010.1-2012.12)
• National High-Tech R&D Program (863)
• "A Next-generation-sequencing-based system for metagenome data collection and analysis"(2009AA02Z310, PI, RMB 1.61M)(2009.1 - 2011.12)
• Shanghai Pujiang Program
• "CRF theory and its application in Bioinformatics"(09PJ1407900, PI, RMB 200k)(2009.8-2011.7)
• Science and Technology Innovation Program of Basic Science Foundation of Shanghai
• "Algorithms and system for complex sequence module finding"(08JC1416700, PI, RMB 250K) (2008.10-2010.9)

 

©2010 Chaochun Wei